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Lithopone is rather nontoxic, due to the insolubility of its components. It has been used in medicine as a radiocontrast agent. Lithopone is allowed to be in contact with foodstuffs in the US and Europe.[1]
Lithopone is manufactured by a process (Fig. 1) in which barium sulfide solution is prepared by reducing barite ore (BaSO 4) with carbon and leaching the resulting mass.